Cellular & Molecular Medicine: Open access

Carcinoma Neuro-Immunology and Accompanying Prodromal Symptoms

The nervous system and immune cells have developed to communicate with one another over time in order to control inflammation and host responses to injury. These pathways are also involved in cancer development and progression, according to recent findings in neuroimmune communication. Multiple nerve types innervate lymphoid tissues and malignancies, which are frequently accompanied with inflammatory infiltrate (e.g. sympathetic, parasympathetic, sensory). Recent preclinical and clinical research show that targeting the brain system could be a therapeutic strategy for boosting antitumor immunity while also alleviating cancer-related neurological symptoms such persistent pain and tiredness.

Author(s):

Julia Anderson

Abstract | PDF

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