As the prevalence of obesity explosively increases worldwide, the rise in the population with metabolic diseases is of great concern. Metabolic alterations can be assessed by typical medical techniques (e.g. tissue biopsy, etc.), however, noninvasive in vivo detection in living tissue was not forthcoming. Magnetic resonance spectroscopy (MRS), which is similar to magnetic resonance imaging (MRI) first appeared in medicine in 1970’s, can detect metabolic changes in vivo noninvasively.