Cellular & Molecular Medicine: Open access

Phytochemical Screening and Ex-Vivo Cardioprotective Assay of Euphorbia hirta (L)

Investigated whole plant extracts of Euphorbia hirta L were used for it possible phytochemistry as well as thrombolysis effect by using its water, ethyl acetate and ethanolic fractioned extracts. Pharmacological history of this plant promoted us to check the possible thrombolysis activities. This article demonstrated the thrombolytic activities of various extracts of Euphorbia hirta L. Whereas ethanol, ethyl acetate and water extracts demonstrated clot lysis 25.81%, 14.17% and 30.48 % respectively. Different conformity tests of the crude extract demonstrated that Euphorbia hirta L consists of various types of glycosides, alkaloids, tannins, flavonoids, triterpenoids etc. In-vitro Euphorbia hirta lyses blood clots. Once found Euphorbia hirta may be integrated as a thrombolytic moiety for the treatment for atherothrombotic diseases. However, the present in-vitro biological evaluation of this plant forms a primary platform for further phytochemical and pharmacological studies. These potential extracts may play vital roles for discovery new clinically effective bioactive compounds. Further investigation might be elucidating, identification of cellular and molecular mechanism of action and purification of active compounds and binding capacity of active molecules with receptors.

Author(s):

Md Reyad-Ul-Ferdous, Mehedi Rahman, Mohammad Atiqur Rahman, Al Imran Ahmed, Md Jahed Rana, Md Ataur Rahman and Hossain Reza

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