Cellular & Molecular Medicine: Open access

AATF Genome: Evolution of Allorecognition

Human AATF genome holds AATF gene and its encoded miR-2909 in its fold, to exhibit “Hysteresis phenomenon” arising out of bi-stable cooperative-activity of these AATF gene-products. This “Hysteresis Mechanism” enables cells, within human tissues, to decouple/couple the glycolysis from/with the aerobic respiration in a fashion that equips them with flexible dynamic programming to read the incoming signals as “Friend” or “Foe” and accordingly write the script for calibrated-response directed specifically/selectively to erase the signals perceived by these cells to be “Foe”. This novel model not only has the ability to explain the existing anomalies in “Allorecognition phenomenon” but may be even more useful for adding a new paradigm for futuristic studies directed to design preventive/ curative immunological-strategies against human diseases.

Author(s):

Deepak Kaul

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