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Connexins as Potential Therapeutic Targets for Testis Pathologies

Male infertility and cancers were recently linked, suggesting shared molecular bases. Because alteration of connexin functions were associated with male infertility and detected in many cancers, it is likely that connexins are one of the molecular machinery involved in the initiation of both pathologies. In addition, chemicals present within our environment can be at the origin of these two pathologies through their action on connexin expression and/or trafficking. However, taking advantage of this knowledge to develop strategies targeting connexins to cure male infertility and cancer still remains challenging.


Jerome Gilleron

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