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Calreticulin and JAK2V617F Mutations in Essential Thrombocythemia and Their Potential Role in Diagnosis and Prognosis

Mutation in calreticulin (CALR) has been recently detected in essential thrombocythemia (ET) patients lacking JAK2V617F mutation. The absence of JAK2V617F mutation in 50% of patients with ET has indicated the importance of new markers for disease diagnosis, including CALR. Considering the detection of CALR in these patients, in this paper we study the structure and function of CALR protein and JAK2V617F as well as their diagnostic and prognostic role in ET patients.


Najmaldin Saki

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